Mazin A.L.
Enzymatic DNA Methylation
as a Mechanism of Aging.
Review.
Molec. Biol., 1994, vol.28, n.1, pp.21-52.  

CONTENTS:

1. Introduction.
2. DNA methylation as generator of mutations.
3. Age-related DNA demethylation.
3.1. Animal genome loses most of m⁵C over life span.
3.2. Ontogeny starts with de novo DNA methylation.
3.3. Age-related m⁵C loss from plant DNA.
3.4. Loss of all m⁵C from DNA coincides with
Hayflick limit.
3.5. How to predict the life span?
4. Accumulation of m⁵C-to-T mutations in genome.
4.1. DNA methylation as evolutionary factor.
4.2. When does the end of the World come?
4.3. Contribution of DNA methylation to general mutability.
5. DNA methylation as a mechanism of aging.
5.1. Senescence as genetically programmed
accumulating mutations.
5.2. DNA methylation as a biomarker of aging:
predictions.
5.3. When and how does senescence start?
5.4. Dynamics of aging and DNA methylation.
5.5. Why do women live longer?
5.6. DNA methylation as a physiological parameter.
5.7. Is it possible not to age?
6. DNA methylation as anti-aging mechanism in
cancer cells.
7. Conclusion.

Design by Levasha © 2003